A campaign to save the life of a man with a rare type of leukaemia has just days to raise £400,000 to send him to the US for revolutionary treatment.
Kate Brandon, 33, has so far raised more than £250,000 towards the costs of her husband Mike's treatment at the University of Pennsylvania.
Mrs Brandon has launched the #donate4Mike campaign on social media to raise the money for her 31-year-old husband's treatment, which is due to begin next Tuesday.
His treatment is funded by the university but the medical costs associated with its administration must be self-funded.
It is the second time the couple, from Bristol, have appealed directly to the public for help after Mr Brandon was diagnosed with acute lymphoblastic leukaemia in 2014 - a month after proposing to his now wife.
A matching donor was found and Mr Brandon underwent a successful transplant on his 30th birthday.
Mr Brandon had battled through the rejection of multiple anti-cancer drugs, undergone more than 20 gruelling bone marrow biopsies, contracted pneumonia and received five further infusions of cells from his donor.
Last summer the couple married but sadly Mr Brandon relapsed at Easter - and the cancer was spreading at an aggressive rate.
In a video posted on their gofundme page, Mrs Brandon said: "I am asking you for help to save my husband Mike Brandon.
"I have reached out to you before with our #Shake4Mike campaign in 2014 when Mike was diagnosed with leukaemia.
"With all the public support we found him a donor and he had his transplant in June 2014.
"Since then it has not been the most straightforward of two years but we have had the last two years together and that's thanks to Anthony Nolan and the public and the hospital.
"I am so grateful for every moment we have had together in the last two years. You feel so much closer to life when you are in this situation and although some bits have been really rough the good times are so, so special.
"I now reach out to you again because Mike has relapsed but this time things are a hell of lot more worse than they were first time round.
"He relapsed at Easter and has very little hope for a full recovery. His only chance is to access this new research trial in America which is looking at CAR T-cell therapy.
"To get him there I need at least £400,000 and I need it as soon as possible.
"I know from the amount of support we had for #Shake4Mike and I know how serious things felt back then we were able to get through it.
"I know with your help we can get through it again. We launched the campaign and it has been such a strong start.
"It is just a pleasure to see my Facebook and Twitter account explode with love and affection.
"Please share this #donate4Mike page. Please donate as much as you can or simply change your profile page to our logo or just spread the word. Tell your friends, tell your family.
"I'm sure you can all imagine losing the most important person to you, so please help me combat what we are facing. I know with your help we can get him where he needs to be."
Mrs Brandon said any extra money raised will be donated to the Bristol Royal Infirmary haematology oncology unit.
The fundraising page can be found at: https://www.gofundme.com/donate4mike