More than three-quarters of police officers and half of paramedics have been injured while dealing with alcohol-related incidents, according to a report.
Police officers blamed 24-hour licensing for the drink-fuelled violence and urged ministers to issue more controls over pubs and clubs opening hours.
The study, undertaken by the Institute for Alcohol Studies, surveyed 5,000 emergency service workers, with 76% of police officers and 50% of ambulance staff saying they had been injured while dealing with drink-related incidents.
Clubs, pubs, bars and supermarkets in England and Wales are allowed to apply for later opening and licensing hours under the 2003 Licensing Act.
One officer told the IAS survey that the move had "changed policing forever", adding that time spent dealing with drink-related crime meant police were not available to patrol residential areas or catch burglars.
Another said: "All-night drinking and ubiquitous cheap available alcohol has changed the face of the UK for the worse."
Officers interviewed for the survey said more than half of their time (53%) was spent dealing with drink-related crime.
The IAS report called for "more assertive" use of licensing powers by local authorities and the introduction of a minimum alcohol price.
IAS director Katherine Brown said: "Our report shows how alcohol takes up a disproportionate share of emergency service time, costing taxpayers billions of pounds each year.
"Many of these incidents are preventable, and alcohol therefore creates unnecessary problems for frontline staff, increasing their workload and preventing them from dealing with other important issues. Police officers we spoke to would far rather be dealing with burglaries than Friday-night drunks."
The report said a "culture of fear" existed among emergency service workers, with more than half of ambulance staff and over a third of police officers saying they had been sexually harassed or abused while dealing with drunk people.
The president of the Royal College of Emergency Medicine, Dr Cliff Mann, welcomed the report.
He said: "We as a college are extremely concerned about the harm attributable to alcohol, including the impact on the ambulance service in the UK and our already hard-pressed emergency departments."
Home Office Minister Mike Penning said the Government was building on the Alcohol Strategy launched in 2012 to tackle drink-related crime.
Mr Penning, who is Minister for Policing, Crime, Criminal Justice and Victims, said: "Our blue-light services do a difficult job protecting our communities and helping the public in times of need. Any assault on a member of the emergency services won't be tolerated, and offenders will feel the full force of the law.
"Alcohol-related harm is estimated to cost society £21 billion per year, of which £11 billion is alcohol-related crime. That is why the Government will build on the Alcohol Strategy launched in 2012 to tackle alcohol as a driver of crime and support people to stay healthy, whilst working with partners at a local and national level to reduce the impact of alcohol misuse on emergency services."
The Home Office added that Minimum Unit Pricing remains under review.
Steve White, chair of the Police Federation of England and Wales, said the report was "no surprise".
He added : "You would be lucky to find a single police officer who hasn't been spat at, kicked or assaulted in some way while dealing with the people spilling out of pubs and clubs at closing time."